Glyceryl Trinitrate Suppository For Anal Fissure: Safety and Efficacy A double-blind placebo-controlled clinical trial concluded that use of glyceryl trinitrate 0.2% suppositories represents a new, promising, and effective treatment for chronic anal fissure. Dis Colon Rectum. 2008 May 10. [Epub ahead of print]Click here to access the PubMed abstract of this article.Short Chain Fatty Acid Enemas for Short-Term Treatment of Chronic Radiation ProctitisRadiation proctitis is a common complication of abdominal and pelvic radiotherapy. Short chain fatty acids are the main energy source of colonocytes and their use may be impaired in chronic radiation proctitis. A prospective, randomized, double-blind trial compared short chain fatty acid enemas with placebo in 19 patients with chronic radiation proctitis. After five weeks, short chain fatty acid-treated patients showed...
A systematic review of the effects of estrogens for symptoms suggestive of overactive bladder.Estrogen therapy may be effective in alleviating the symptoms suggestive of OAB. Local administration may be the most beneficial route of administration.Acta Obstet Gynecol Scand. 2004 Oct;83(10):892-7Click here to access the PubMed abstract of this article. Androgens to Strengthen Muscles of Female Pelvic Floor and Lower Urinary TractCurr Opin Obstet Gynecol. 2004 Oct;16(5):405-9.Click here to access the PubMed abstract of this article. Progesterone Cream: Effects and Side-effects on Skin of Peri- and Postmenopausal Women This study demonstrates that topical 2% progesterone increases elasticity and firmness in the skin of peri- and postmenopausal women. These effects in combination with good tolerability make progesterone a possible treatment agent for slowing down the...
Pharmacists Helping Vets and Pets Our "specialty service should not be viewed as competition with local veterinarians; rather, compounding allows veterinarians to broaden their prescribing abilities and to offer [dosage] forms that are patient-specific in strength and formulation. Therefore, the goal of compounding for the veterinary patient is to enhance the veterinarian's ability to treat patients in a more effective and efficient manner... "Compounding can make medicating animals easier if the pharmacist prepares flavored chews that animals accept readily. For example, tranquilizing a feral cat with a liver-flavored chew eliminates the possibility of over- or underdosing. If a chew contains 10mg acepromazine and the dose fails to gain a response, a second flavored chew can be given to the...
Topical vs. Transdermal TopicalPeripheral tissue activitySystemic side effects less likelyIf analgesic, applied directly over painful siteInsignificant serum levels TransdermalSystemic activityPotential for adverse effectsIf analgesic, may be applied away from painful siteSerum levels necessary for effect Medications that relieve pain, reduce inflammation, and relax muscles can have side effects that are detrimental to athletic performance, such as drowsiness. However, when these medications are administered topically, the therapeutic benefit can be enhanced while significantly reducing the risk of adverse effects. For example, research has shown that topically-applied ketoprofen provides a high local concentration of drug below the site of application but decreases systemic exposure and significantly reduces the risk of gastrointestinal upset or bleeding. When properly compounded into an appropriate base, tissue...
Adrenal FatigueThe adrenal glands secrete hormones such as cortisol, estrogen, and testosterone that are essential to health and vitality and significantly affect total body function. After mid-life, the adrenal glands gradually become the major endogenous source of sex hormones in both men and women. Intense or prolonged physical or emotional stress commonly associated with modern lifestyles or chronic illness can lead to Adrenal Fatigue, which is an important contributing factor in health conditions ranging from allergies to obesity. Anti-inflammatory and anti-oxidant adrenal hormones like cortisol help to minimize allergic and negative reactions, such as cancer and autoimmune disorders. These hormones closely affect the utilization of carbohydrates and fats, the conversion of fats and proteins into energy, and cardiovascular and gastrointestinal...
