Glyceryl Trinitrate Suppository For Anal Fissure: Safety and Efficacy
A double-blind placebo-controlled clinical trial concluded that use of glyceryl trinitrate 0.2% suppositories represents a new, promising, and effective treatment for chronic anal fissure.
Dis Colon Rectum. 2008 May 10. [Epub ahead of print]
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Short Chain Fatty Acid Enemas for Short-Term Treatment of Chronic Radiation Proctitis
Radiation proctitis is a common complication of abdominal and pelvic radiotherapy. Short chain fatty acids are the main energy source of colonocytes and their use may be impaired in chronic radiation proctitis. A prospective, randomized, double-blind trial compared short chain fatty acid enemas with placebo in 19 patients with chronic radiation proctitis. After five weeks, short chain fatty acid-treated patients showed a significant decrease in the number of days with rectal bleeding from the previous week and an improvement of endoscopic score. The study concluded that short chain fatty acid enemas can accelerate the process of healing in chronic radiation proctitis, but treatment has to be continuous if a complete and sustained clinical, endoscopic, and histologic response is to be obtained.
Dis Colon Rectum. 1999 Jun;42(6):788-95; discussion 795-6.
Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial.
Pinto A, Fidalgo P, Cravo M, Midões J, Chaves P, Rosa J, dos Anjos Brito M, Leitão CN.
Serviço de Gastrenterologia, Lisboa, Portugal.
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Am J Gastroenterol. 1996 Sep;91(9):1814-6
Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis.
al Sabbagh, R : Sinicrope, F A : Sellin, J H : Shen, Y : Roubein, L
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Topical Metronidazole 10% Decreases Posthemorrhoidectomy Pain and Improves Healing
Oral metronidazole has been demonstrated to decrease postoperative pain after open diathermy hemorrhoidectomy. A prospective, randomized trial at the Georgia Colon and Rectal Surgical Clinic in Atlanta, Georgia investigated the efficacy of topical metronidazole 10% vs. placebo, applied to the surgical site, in reducing postoperative pain and promoting wound healing after Harmonic Scalpel hemorrhoidectomy. In the metronidazole group, postoperative edema was ranked significantly lower and overall wound healing ranked significantly better than in controls. The study concluded that topical 10% metronidazole significantly reduces post-hemorrhoidectomy discomfort on postop days 7 and 14. Postoperative edema is reduced and overall healing is improved, compared with placebo.1
A separate double-blind, randomized trial evaluated the effect of topical metronidazole 10% versus placebo, applied to surgical site, in reducing postoperative and post-defecation pain after hemorrhoidectomy. Findings indicated that topical 10% metronidazole significantly reduces post-hemorrhoidectomy discomfort. 2
1 Dis Colon Rectum 2004 May;47(5):711-6
Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing.
Nicholson TJ, Armstrong D.
Georgia Colon and Rectal Surgical Clinic, Atlanta, Georgia 30342, USA.
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2 Dis Colon Rectum. 2008 Feb;51(2):235-8. Epub 2008 Jan 4
Topical Metronidazole can Reduce Pain after Surgery and Pain on Defecation in Postoperative Hemorrhoidectomy.
Ala S, Saeedi M, Eshghi F, Mirzabeygi P.
Faculty of Pharmacy, Clinical Pharmacy, Mazandaran University of Medical Sciences, P.O. Box 48175-861, Sari, Mazandaran Province, Iran
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